Modern medicine has no treatment methods to eliminate GHB from the human body. Therefore, the aim of therapeutic measures is:
- suppressing the reproduction of GHB during the period of exacerbation (stopping a relapse);
- formation of an adequate immune response and its long-term preservation in order to block the reactivation of GHG in foci of persistence.
- Currently, there are two main directions in the treatment of herpes simplex.
The use of antiviral chemotherapy, which occupies a leading position in acute herpetic infection with lesions of the CNS and other systems and organs, as well as herpes in newborns. Antiviral drugs are very important in the treatment of recurrent forms of herpes simplex with lesions of the skin and mucous membranes. The main place in antiviral therapy is given to acyclic nucleosides and, first of all, to preparations containing acyclovir (ACV): zovirax, herperax, valtrex, acyclovir-acri, famvir, etc. In cases of intolerance to ACE drugs are used drugs with another mechanism of antiviral action.
There are two fundamentally different approaches to the prescription of antiherpetic chemopreparations:
episodic treatment – taking ACV drugs at the moment of relapse in therapeutic doses, while maintaining the frequency and duration of treatment;
suppressive therapy – long, sometimes long-term, continuous use of ACE medication outside of relapse in lower doses.
- Complex treatment method, including immunotherapy (specific and non-specific) in combination with antiviral therapy.
Nonspecific immunotherapy is used to perform nonspecific immunotherapy:
- immunoglobulin, normal human for intramuscular administration; in case of CNS injuries, neonatal herpes, infusion forms of immunoglobulin are recommended;
- interferon (IF) (substitution therapy).
- In practical health care, human leukocyte interferon (HLI) is currently used in several dosage forms: 1) Nasal drops; 2) PUI for injection – a mixture of interferon-alpha produced by leukocytes of clinically healthy donors (activity of one dose of the drug is 100 thousand ME, 500 thousand ME, 500 thousand ME). 3) leukinferon (for injection) is a natural complex preparation containing interferon-alpha and cytokines (one dose – 10 thousand ME); 4) interlock (for injection), in 1.0 ml – 50 thousand ME; 5) PUI in rectal candles (in one candle – 40 thousand ME antiviral activity).
For the treatment of various forms of recurrent herpes, preparations containing alpha-2-genetically engineered interferon – reaferon, which is part of the domestic rectal candles vipheron, are used. The combined preparation kipferon consisting of immunoglobulins and reaferon in the form of suppositories for rectal and vaginal administration was created;
preparations – interferon inductors.
Amixin, arbidol, alpisarin, and flacoside, being inducers of IF, stimulate production of endogenous IF in the patient’s body. This explains the positive therapeutic effect of these products in many viral diseases (recurrent herpes, influenza, adenoviral infection, etc.), which allows recommending them in the comprehensive treatment of herpes viral infections, especially in patients with frequent colds and acute respiratory infections.
The ability to induce production of endogenous IF has a large group of natural and synthetic compounds: levamizole (decaris), dibazole, vitamin B12, pyrogenal, prodigiosan, which are drugs of choice in the treatment of herpes;
preparations stimulating T- and B-links of cellular immunity and phagocytosis.
To stimulate T- and B-links of cellular immunity in patients with recurrent herpes, tactivin, thymalin, thymogen, myelopid, etc. are successfully used. The treatment should be performed under the control of immunogram.
Specific immunotherapy consists in the use of domestic herpetic vaccine (polyvalent, tissue, killed). Therapeutic effect of the vaccine is connected with stimulation of specific reactions of antiviral immunity, restoration of functional activity of immunocompetent cells and specific desensitization of organism.