Infection of sensory ganglia of the autonomic nervous system and lifelong persistence of GI in them is one of the important stages in the pathogenesis of GI. In herpes the face is the sensitive ganglia of the trigeminal nerve, in herpes the genital ganglia of the lumbosacral spine serves as a reservoir of the virus for sexual transmission.

Under certain conditions, GHB multiplies in T- and B-lymphocytes of the patient, which leads to the defeat of immunocompetent cells and secondary immunodeficiency, which is clinically manifested by frequent colds, reduced performance, appearance of subfebrilic body temperature, lymphadenopathy, psychoasthenia.

Tropism of VPH to epithelial and nerve cells causes polymorphism of clinical manifestations of herpetic infection.
The peculiarity of the pain syndrome in recurrent herpes (RH) is that it can occur periodically regardless of skin manifestations, which greatly complicates its diagnosis. In case of herpes, the face may have intense pain along the twigs of the trigeminal nerve, pain in the outer ear canal, which forces patients to see dentists and ENT doctors. Pelvic neuralgia is often found in GH. Irritation of parasympathetic fibers causes subjective sensations in patients in the form of burning, which is a pathognomonic symptom in GH.

Herpes disease pathogenesis

The recurrent herpes develops in 30-50% of the population infected with GH. Acute herpetic infection may be triggered by hypothermia, insolation (“solar” herpes of the face in hot countries), mental or physical trauma (dental or gynecological manipulations), alcohol intake, hormonal cycles (“menstrual herpes”) and others.

The frequency and intensity of exacerbations in recurrent herpes depend on the virulence and pathogenicity of the causative agent, as well as the resistance of the human body.

Symptoms of intoxication in patients during relapses are caused by viruses: general weakness, malaise, subfebrile body temperature, increase and painfulness of peripheral lymph nodes. Their appearance indicates the dispersion of infection, the inability of the immune system to localize the process.

Repetitive genital herpes (RGH) is one of the most common infectious diseases of the genitourinary system. The disease is difficult to treat, is characterized by chronic course, violation of sexual and reproductive function of the patient, which often leads to the development of neurasthenia.

Localization of lesions on the genitals is determined by the “entry gate” of infection. In men, rashes are usually located in the area of the outer and inner leaves of the foreskin, corolla, rook-shaped fossa. Less frequently affected are the head and body of the penis, scrotum skin. In women, herpetic rashes may appear on the large and small labia, the mucous membrane of the vagina, cervical uterus, in the crotch.

Speaking of genital herpes, it should be remembered that we are talking not only about the lesions of the skin and mucous membranes of the external genitalia (typical, atypical form of herpes), but also about GHG lesions of the internal genitalia.

Herpes disease pathogenesis

Small pelvic herpetic infection (SPT) may be represented by clinically distinct and asymptomatic forms.

Involvement of the nervous system in the infectious process is found in about 30% of patients with recurrent GH, and is often the only clinical symptom of internal genital GI. In this case, women complain of recurrent pulling pains in the lower abdomen, in the ovarian projection area, irradiation of the lumbar region and rectum, and pain in the perineum. Men point to intermittent pains in the crotch, pulling sensations in the scrotum, in the body of the penis. In some cases, the pain syndrome may mimic the “acute abdomen” clinic.

It should be noted that the role of acute abdominal pain in the development of pathological processes in the male body is clearly underestimated by physicians. At the same time, in men suffering from chronic inflammatory diseases of the pelvic organs, it is possible to detect GHG in 50-60% of cases in the detached from the genitourinary system organs. It has been shown that GHG is an agent that violates spermatogenesis and has the ability to infect sperm, which is particularly important in men of reproductive age and opens up new aspects in interpreting and solving the problem of infertile marriage.

The high prevalence of asymptomatic and undiagnosed forms of herpes is the most difficult health problem. They are the ones that have serious importance in the spread of GI in the population.